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Due to its long half-life, Tirzepatide can continue to exert metabolic effects for several weeks after the last dose, especially a high dose of Tirzepatide

Until we have larger, more definitive studies, the safest approach is still to stop GLP-1 medications before trying to conceive. The findings, however, are exactly the kind of data we need to justify properly designed prospective trials, says Lora Shahine, MD, a reproductive endocrinologist and obstetrician-gynecologist at PNWF IVY Fertility Center in Bellevue, Washington, and host of the Brave and Curious podcast

Research shows that some medications in these classes may reduce the risk of cardiovascular conditions like heart failure, stroke, and kidney disease

Prades R, Teixid M, Oller-Salvia B (2025) New trends in brain shuttle peptides

Pancreatitis, an inflammation of the pancreas, has been reported in some cases